Rheumatoid Arthritis Models

野生マウス750
Wild Mouse 750
Human Xenograft Models
Cell Derived Xenograft Models
自己免疫疾患モデル
Rheumatoid Arthritis ModelsPsoriasis ModelsInflammatory Bowel Disease ModelsAtopic Dermatitis Models Asthma Models
代謝性疾患マウスモデル
Obesity ModelsDiabetes ModelsMASH ModelsHyperlipidemia ModelsOsteoporosis ModelsHyperuricemia Models
Humanized Immune System Models
huPBMC-NCGhuHSC-NCG-XhuHSC-NCG-hIL15huHSC-NCG
Organs or Tissue Humanized Mouse Models
野生マウス765
Wild Mouse 765
腫瘍免疫学マウスモデル
Human Xenograft ModelsHumanized Immune Checkpoint ModelsHumanized Immune System ModelsSpontaneous Tumor Models
神経変性疾患マウスモデル
Alzheimer’s Disease (AD) ModelsParkinson’s Disease (PD) ModelsHuntington's Disease (HD) ModelsAmyotrophic Lateral Sclerosis (ALS) ModelsTransthyretin Amyloidosis (ATTR) Models
希少疾患マウスモデル
Progressive Muscular Dystrophy ModelsHemophilia A Models

The type II collagen-induced arthritis (CIA) mouse model is the most widely used model to study rheumatoid arthritis (RA). CIA model can be used for preclinical studies and efficacy evaluation of RA therapeutics.


Modeling strategy

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Validation data

  1. Phenotypic data of CIA model (DBA1/J)

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An adjuvant containing bovine collagen type II was injected subcutaneously into the tail of mice. The forelimbs, hindlimbs and paws of the mice were observed and scored weekly. The score of the arthritis group was significantly higher than that of the control group. 10 weeks after the first immunization, the paw of the hind limb showed obvious swelling in the CIA mice (yellow arrowheads).


  2. Efficacy Results of anti-IL17A drugs in CIA Models (DBA-hIL17A)

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DBA-hIL17A mice were used for CIA, and administered with Cosentyx (Secukinumab) and test drug X (targeting hIL17A). The results showed that the two drugs had therapeutic effects on DBA-hIL17A arthritis mice.