疾患マウスモデル

ヒトの疾患研究において重要なツールとしてのモデル動物は、疾患メカニズムの調査や治療法の開発に役立ちます。最も広く使用されているモデル動物の一つであるマウスは、基礎科学研究、新薬の発見、前臨床評価、臨床技術の開発など、さまざまな分野で使用されています。マウスはヒトと密接な関係を持ち、高度な遺伝子編集、迅速な繁殖、明確な遺伝的背景を持っています。遺伝子編集技術は、疾患関連遺伝子に基づいた研究用の適切な疾患モデルを提供できます。GemPharmatechは、遺伝子編集技術を使用してさまざまな疾患モデルを作製しており、これには自然発症の腫瘍モデル、肥満モデル、糖尿病モデル、アルツハイマー病モデル、パーキンソン病モデルなどが含まれます。表現型解析を通じて、GemPharmatechは多くのモデル関連表現型の発生と進行を確認し、さまざまな疾患の研究を支える基盤的なサポートを提供しています。

GemPharmatechの最 新マウスをご紹介:イノベーションの幕開け


Strain ID

Strain Name

Application

T055223


B6-Tg(hSOD1 G93A,hSOD1) 图片1.png

Genetic humanization, ALS disease

T058996

FAD4T-hTREM2 图片1.png

Genetic humanization, Alzheimer's disease

T054322

B6-hSNCA E46K A53T

Genetic humanization, Parkinson's disease

T056757

B6-hCD36

Genetic humanization, neuroinflammation

T056002

B6-Dmd Del45

Duchenne muscular dystrophy, 45 exon deletion

T055631

B6-hDLL4

Genetic humanization, oncology

T056429

B6-hCD34

Genetic humanization, oncology

T058753

B6-hCEACAM5-Tg

Genetic humanization, oncology

T053316

B6-hIL18R1/hIL18RAP

Genetic humanization, oncology

T037007

B6-hCD47/hSIRPA 图片1.png

Genetic humanization, oncology

T056010

BALB/c-hCD44

Genetic humanization, oncology

T054198

BALB/c-hGPC3

Genetic humanization, oncology

T054490

BALB/c-hSEMA4D

Genetic humanization, oncology

T054543

BALB/c-hHSA

Genetic humanization, oncology

T056432

BALB/c-hTROP2 图片1.png

Genetic humanization, oncology

T056011

BALB/c-hCD44v6

Genetic humanization, oncology

T055714

BALB/c-hCS1

Genetic humanization, oncology

T056083

BALB/c-hLRRC15

Genetic humanization, oncology

T056430

BALB/c-hNECTIN-4

Genetic humanization, oncology

T058266

BALB/c-hTIGIT/hPVRIG

Genetic humanization, oncology

T054842

BALB/c-hPD1/hPDL1/hTIGIT/hCD9 图片1.png

Genetic humanization, oncology

T058749

BALB/c-hPD1/hPDL1/hCD73/hCD39 图片1.png

Genetic humanization, oncology

T009819


BALB/c-hHER2 图片1.png


Genetic humanization, oncology

T009813

NCG-hHER2

Genetic humanization, oncology

T054081

NOD-Scid-hNKp30

Genetic humanization, oncology

T056195

B6-hIGHA1

Genetic humanization, autoimmune disease


T054583

BALB/c-hIL1RL1

Genetic humanization, autoimmune disease

T054645

BALB/c-hKLRB1

Genetic humanization, autoimmune disease

T003277

BALB/c-hIL17A 图片1.png

Genetic humanization, autoimmune disease

T053555

BALB/c-hIL1β

Genetic humanization, autoimmune disease

T054186

BALB/c-hTLR8

Genetic humanization, autoimmune disease

T055268

BALB/c-hFcgRs/hCD47/hSIRPA 图片1.png

Genetic humanization, Fc end modification for antibody drugs, ADCC effect

T058940

BALB/c-hCD3EDG/hCD22

Genetic humanization, CD3 bispecific antibody related

T057420

BALB/c-hCD73/hCD3EDG 

Genetic humanization, CD3 bispecific antibody related

T058817

BALB/c-hGPRC5D/hCD3EDG 图片1.png

Genetic humanization, CD3 bispecific antibody related

T059045

BALB/c-hCD3EDG/hBCMA 图片1.png

Genetic humanization, CD3 bispecific antibody related

T058351

B6-Rosa26-hAGT 图片1.png

Genetic humanization, hypertension

T058352

B6-H11-hREN

Genetic humanization, hypertension

T054639

B6-hCD200R1

Genetic humanization, atherosclerosis research

T058217

B6-hAPOB-Tg

Genetic humanization, hypercholesteremia and atherogenesis

T058211

B6-hAPOE-DGAT2-LE1 图片1.png

Genetic humanization, NASH

T051403

B6-Myh6-R404Q 图片1.png

Hypertrophic cardiomyopathy

T027708

B6-Mybpc3-KO

hypertrophic cardiomyopathy or dilated cardiomyopathy

T007085

B6-Kras-G12D/wt; Lyz2-iCre

Spontaneous lung cancer

T053603

kras-G12C 图片1.png

Kras-related spontaneous tumors

T057165

KPS 图片1.png

Spontaneous lung cancer

T057162

KS

Spontaneous lung cancer