Ldlr KO Models
The Low-Density Lipoprotein Receptor (LDLR) is a member of the lipoprotein receptor family that clears low-density lipoprotein (LDL) and intermediate-density lipoprotein (IDL) to regulate plasma cholesterol levels. GemPharmatech generated an LDLR knockout mouse on the C57BL/6 background by using CRISPR/Cas9 technology. In LDLR knockout mice, the introduction of a western diet can promote the incidence and development of atherosclerosis.
Strain: B6/JGpt-Ldlrem1Cd82/Gpt
Number of lab animals: 5-10 per group, 3-8 groups
Data Validation:
Plasma Chol and LDL-C
Figure 1. Under normal or western diet conditions, plasma cholesterol and LDL levels were shown to be increased in ldlr-/- mice. Data are presented as Mean±SEM.
2. Pathology
Figure 2. Elevated levels of plasma cholesterol and LDL were observed in ApoE-/- mice either under normal and western diet.
Efficacy Data:
1. Plasma Chol, LDL-C and TG
Figure 3. MGL-3196 reduced total cholesterol, LDL, and triglyceride levels in the Ldlr KO model. The data are presented as Mean±SD, n=6. *，P<0.05 by unpaired two-tailed student's t-test.