Diabetes mellitus is a common disease caused by genetic, environmental, and immunological factors resulting in islet hypofunction and insulin resistance, and revealing complex metabolic disorders involving sugar, protein, fat, water, and electrolytes. More than 90% of patients with diabetes have type II diabetes(T2D). GemPharmatech has generated the matching diabetes mellitus models using gene-editing technology and a diet-induced modeling approach for researching type II diabetes mellitus pathogenesis as well as evaluating therapeutic medication screening.